D81 ICD-10-CM Code: Combined immunodeficiencies
A clear reference for the official code description, hierarchy, and related coding information from the FY 2027 U.S. release.
Official description
D81Combined immunodeficiencies
ICD-10-CM diagnosis code · United States clinical modification
Where D81 sits
- 1
Chapter 3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- 2
Section
Certain disorders involving the immune mechanism (D80-D89)
- 3
Category D81
Combined immunodeficiencies
- 4
Code D81
Combined immunodeficiencies
Codes under D81
D81 is a non-billable category. Choose the child code that best matches the documented diagnosis.
D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesisD81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbersD81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbersD81.3Adenosine deaminase [ADA] deficiencyD81.4Nezelof's syndromeD81.5Purine nucleoside phosphorylase [PNP] deficiencyD81.6Major histocompatibility complex class I deficiencyD81.7Major histocompatibility complex class II deficiencyD81.8Other combined immunodeficienciesD81.9Combined immunodeficiency, unspecifiedNotes for this code
Inclusion terms
No inclusion terms are listed for D81.
Code first
No “code first” instruction is listed for D81.
Use additional code
No “use additional code” instruction is listed for D81.
Excludes1
Conditions that should not be reported together with this code.
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Excludes2
Conditions not included here that may be reported separately when present.
No Excludes2 note is listed for D81.
Source and release
- Data release
- U.S. ICD-10-CM · FY 2027
- Effective date
- Oct 1, 2026
- Publisher
- Vero Scribe Inc.
This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.
Frequently asked questions
What does ICD-10-CM code D81 mean?
D81 is the FY 2027 U.S. ICD-10-CM code for “Combined immunodeficiencies.”
Is D81 a billable or specific ICD-10-CM code?
No. D81 has more specific child codes in the FY 2027 reference data. Select the code that matches the documentation and confirm the active code set and payer requirements.
Where is D81 located in ICD-10-CM?
D81 is listed in Chapter 3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), within Certain disorders involving the immune mechanism (D80-D89) (D80–D89), under category D81, Combined immunodeficiencies.
What coding notes are listed for D81?
No inclusion terms are listed for D81 in this reference record. No code-first instruction is listed. Excludes1 notes: autosomal recessive agammaglobulinemia (Swiss type) (D80.0). No Excludes2 note is listed.