U.S. ICD-10-CM · FY 2027

D81 ICD-10-CM Code: Combined immunodeficiencies

A clear reference for the official code description, hierarchy, and related coding information from the FY 2027 U.S. release.

Code definition

Official description

D81

Combined immunodeficiencies

ICD-10-CM diagnosis code · United States clinical modification

Classification

Where D81 sits

  1. 1

    Chapter 3

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

  2. 2

    Section

    Certain disorders involving the immune mechanism (D80-D89)

  3. 3

    Category D81

    Combined immunodeficiencies

  4. 4

    Code D81

    Combined immunodeficiencies

More specific choices

Codes under D81

D81 is a non-billable category. Choose the child code that best matches the documented diagnosis.

D81.0

Severe combined immunodeficiency [SCID] with reticular dysgenesis

D81.1

Severe combined immunodeficiency [SCID] with low T- and B-cell numbers

D81.2

Severe combined immunodeficiency [SCID] with low or normal B-cell numbers

D81.3

Adenosine deaminase [ADA] deficiency

D81.4

Nezelof's syndrome

D81.5

Purine nucleoside phosphorylase [PNP] deficiency

D81.6

Major histocompatibility complex class I deficiency

D81.7

Major histocompatibility complex class II deficiency

D81.8

Other combined immunodeficiencies

D81.9

Combined immunodeficiency, unspecified

Documentation details

Notes for this code

Inclusion terms

No inclusion terms are listed for D81.

Code first

No “code first” instruction is listed for D81.

Use additional code

No “use additional code” instruction is listed for D81.

Excludes1

Conditions that should not be reported together with this code.

  • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Excludes2

Conditions not included here that may be reported separately when present.

No Excludes2 note is listed for D81.

Transparency

Source and release

Data release

U.S. ICD-10-CM · FY 2027

Effective date

Oct 1, 2026

Publisher

Vero Scribe Inc.

This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.

Review the CDC/NCHS ICD-10-CM source

Code-specific guidance

Frequently asked questions

What does ICD-10-CM code D81 mean?

D81 is the FY 2027 U.S. ICD-10-CM code for “Combined immunodeficiencies.”

Is D81 a billable or specific ICD-10-CM code?

No. D81 has more specific child codes in the FY 2027 reference data. Select the code that matches the documentation and confirm the active code set and payer requirements.

Where is D81 located in ICD-10-CM?

D81 is listed in Chapter 3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), within Certain disorders involving the immune mechanism (D80-D89) (D80–D89), under category D81, Combined immunodeficiencies.

What coding notes are listed for D81?

No inclusion terms are listed for D81 in this reference record. No code-first instruction is listed. Excludes1 notes: autosomal recessive agammaglobulinemia (Swiss type) (D80.0). No Excludes2 note is listed.

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