COWS: Clinical Opiate Withdrawal Scale

The COWS rates eleven signs of opioid withdrawal at the bedside, from the resting pulse to gooseflesh skin. Its total, from 0 to 48, shows how severe withdrawal is right now and helps time the first dose of buprenorphine. See the eleven signs, what each band means, and how protocols use the score, then record the result with the free template.

  • Score bands explained
  • Recording template to copy
  • Two recorded examples

COWS result template

Free
COWS ASSESSMENT

Date and time: [Date, clock time]
Patient: [Name or ID, age]
Location: [Emergency department, inpatient unit, withdrawal management, clinic, or other]
Rated by: [Name, credentials]
Purpose: [Baseline, before a first buprenorphine dose, after a dose, taper check, or new symptoms]

OPIOID HISTORY
Last opioid: [Which opioid, route, and usual daily amount]
Time of last use: [Date and clock time; hours since]
Fentanyl exposure: [Known, possible, unlikely, or test result]
Current treatment: [Methadone or buprenorphine dose and time of the last dose, taper step, or none]
Other substances: [Alcohol, benzodiazepines, stimulants, or none]

VITALS
Pulse at rest: [Beats a minute after one minute still]
BP and temperature: [Readings]
Fluids: [Vomiting or diarrhea in the past day, and whether fluids stay down]

SIGN SCORES
Resting pulse: [Points]
Sweating: [Points]
Restlessness: [Points]
Pupil size: [Points]
Bone or joint aches: [Points]
Runny nose or tearing: [Points]
GI upset: [Points]
Tremor: [Points]
Yawning: [Points]
Anxiety or irritability: [Points]
Gooseflesh skin: [Points]
Total score: [0 to 48]
Severity: [No active withdrawal, mild, moderate, moderately severe, or severe]
Not counted: [Any sign left out because another cause explains it, or none]

TREATMENT GIVEN
Opioid treatment: [Drug, dose, route, and clock time; or none, and why]
Symptom relief: [Clonidine, loperamide, antiemetic, pain relief, or none]
Response: [Effect seen, or precipitated withdrawal suspected]

REASSESSMENT
Next COWS due: [Clock time and interval]
Call the prescriber if: [Score limit, a rise after a dose, vital sign limits, or heavy vomiting]
Naloxone: [Kit given and use taught, already has one, or declined]
Handover: [Who was told, and when]

Get the official COWS from its source.

Who holds it

Developed by Drs. Donald R. Wesson and Walter Ling, and published in the Journal of Psychoactive Drugs in 2003.

How you may use it

Wesson and Ling appended a version of the COWS to their 2003 paper for clinicians to copy and use in patient care, and many health services post free copies. The full form, with the wording for each level of each sign, is in the paper; this page names the eleven signs and helps you record the result.

Use it for

  • Emergency departments
  • Buprenorphine starts
  • Withdrawal management units
  • Hospital wards
  • Methadone and buprenorphine tapers
  • Addiction medicine clinics

What the score means. 0 to 48.

0 to 4: No active withdrawal

No meaningful withdrawal now. Too early for a standard buprenorphine start: score again in an hour or two, or consider a low-dose start. On a taper, the current step is holding.

5 to 12: Mild

Withdrawal has begun. Treat the symptoms as needed. Many protocols start buprenorphine from a score of 8 or more; others wait for a higher score, especially after fentanyl or methadone.

13 to 24: Moderate

Clear withdrawal. Most protocols start or continue buprenorphine here, or give the next methadone dose, with medicines for the symptoms, and score again after each dose.

25 to 36: Moderately severe

Marked withdrawal. Treat promptly, check fluids and electrolytes when vomiting or diarrhea is heavy, and score again often.

37 to 48: Severe

Severe withdrawal. Treat now, look for dehydration and other causes, and call for a medical review. A sudden jump soon after a buprenorphine dose suggests precipitated withdrawal.
  • Rate each of the eleven signs and add them for a total from 0 to 48. Each sign scores from 0 up to 4 or 5 points, and the official form describes what each level looks like.
  • The form gives four bands: 5 to 12 mild, 13 to 24 moderate, 25 to 36 moderately severe, and more than 36 severe. A total under 5 is usually read as no active withdrawal.
  • Rate each sign only as far as it seems due to opioid withdrawal. A pulse raised by the walk to the room, or watery eyes from hay fever, doesn’t add to the score.
  • Take the resting pulse after the patient has sat or lain still for a minute.
  • For a standard buprenorphine start, most protocols wait for at least mild to moderate withdrawal, often a COWS of 8 to 12 or more, so the first dose doesn’t precipitate withdrawal. Some wait for 13 or more after fentanyl or methadone.
  • Low-dose starts, which overlap small, rising buprenorphine doses with the opioid the patient already takes, don’t wait for withdrawal. The COWS still tracks symptoms along the way.
  • Score again 30 to 60 minutes after each buprenorphine dose. A fall shows the dose is working. A sharp rise soon after the first dose suggests precipitated withdrawal, which many protocols treat with more buprenorphine and medicines for the symptoms.
  • Fentanyl makes the timing less predictable. It builds up in the body with daily use, and precipitated withdrawal is more common even after the usual wait. Ask what was used, and test for fentanyl where you can.
  • The objective signs, such as large pupils, yawning, a runny nose, and gooseflesh, carry the most weight in confirming withdrawal. Anxiety, aches, and stomach upset have many other causes.
  • The COWS measures withdrawal now. It doesn’t diagnose opioid use disorder or set the long-term dose.

How to give it, score it, and read it.

What to ask first

Find out which opioid was used, how much, and when. The same score means something different 8 hours after heroin and 2 days after the last methadone dose.

  • The opioid, the route, and the usual daily amount
  • The time of the last use, as a clock time, not “this morning”
  • Whether fentanyl is likely: from the patient, the local supply, or a test
  • Any methadone or buprenorphine, with the dose and the time it was last taken
  • Alcohol and sedatives, which can need their own withdrawal plan

Avoid: Scoring before you know the time of the last use. A low score 6 hours after use and a low score 30 hours after use lead to different plans.

Scoring the signs

Most of the eleven signs are seen; aches, stomach upset, and anxiety are asked about as well. The assessment takes a few minutes, close to the patient.

  • Take the resting pulse after the patient has sat or lain still for a minute
  • Judge the pupils in ordinary room light
  • Watch for yawning and restlessness through the whole assessment, and check tremor with the hands held out
  • Use the official form’s description of each level, not a guess
  • Leave out a sign that another cause explains, such as a fever raising the pulse, and note it

Avoid: Rating pupils and gooseflesh from the doorway. They are the most telling signs, and they need a close look.

Reading the total

Add the eleven scores for a total from 0 to 48. The band shows how severe withdrawal is now.

  • 0 to 4: no active withdrawal
  • 5 to 12: mild withdrawal
  • 13 to 24: moderate withdrawal
  • 25 to 36: moderately severe withdrawal
  • More than 36: severe withdrawal

Avoid: Reading one score on its own. Compare it with the time since the last use and the last score: is withdrawal building, peaking, or settling?

Timing buprenorphine

Buprenorphine binds to opioid receptors more tightly than heroin, fentanyl, or methadone, but switches them on less. Given too early, it pushes the other opioid off and causes sudden withdrawal.

  • Wait for at least mild to moderate withdrawal before a standard start, often a COWS of 8 to 12 or more
  • Some protocols wait for 13 or more after fentanyl or methadone
  • Record the first dose next to the score that cleared it, commonly 2 to 8 mg by protocol
  • Score again 30 to 60 minutes later before giving more
  • Consider a low-dose start when the patient can’t wait for withdrawal

Avoid: Giving the first dose on hours since use alone. Score the COWS first, every time.

Tapers and repeat checks

During a methadone or buprenorphine taper, or while withdrawal runs its course, the COWS shows whether the current step is bearable.

  • Score at the same times each day, such as before the dose and late in the day
  • Treat symptoms with clonidine, loperamide, an antiemetic, or pain relief by protocol
  • Slow the taper when scores keep climbing into the moderate range
  • Give naloxone and teach its use before discharge, since tolerance falls quickly

Two recorded results. Every part, filled in.

Each one follows the recording template. Use them to judge how much to write.

COWS result: moderate withdrawal, buprenorphine started

Emergency department, walk-in asking for help with withdrawal, rated by the emergency physician

Opioid history

31-year-old man. Injects heroin, about half a gram a day, for 3 years. Last use at 18:00 yesterday, 16 hours before this check. Urine positive for fentanyl as well as opiates; he thinks his supply is cut with it. No methadone or buprenorphine now. No alcohol or benzodiazepines in the past week.

Vitals

10:00: pulse 104 after a minute seated, BP 142/88, temperature 37.2 °C, oxygen saturation 98%. Vomited twice overnight; keeping water down.

Sign scores

Resting pulse 2, sweating 1, restlessness 1, pupil size 2, bone or joint aches 2, runny nose or tearing 2, GI upset 2, tremor 0, yawning 1, anxiety or irritability 1, gooseflesh 0. Total 14, moderate. Nothing left out.

Treatment given

Buprenorphine 4 mg sublingual at 10:15: the department starts at a COWS of 13 or more when fentanyl is likely. Ondansetron 4 mg by mouth at 10:15 for nausea.

Reassessment

11:15: total 7, mild, pulse 90. No rise, so no sign of precipitated withdrawal. Second dose of buprenorphine 4 mg at 11:20, 8 mg so far. 12:20: total 3, pulse 84, comfortable. Discharged with buprenorphine-naloxone 16 mg daily until his addiction clinic visit in 2 days. Naloxone kit given and use taught. Told to return for vomiting he can’t control or withdrawal that comes back worse.

Common mistakes, and how to avoid them.

Starting buprenorphine by the clock

Hours since the last use are a guide, not a green light. A low score at 14 hours, especially after fentanyl, means the first dose could precipitate withdrawal. Score first.

Counting signs with another cause

A fast pulse from pain or fever, or a runny nose from a cold, isn’t withdrawal. Rate each sign only as far as withdrawal explains it, and note what you left out.

Skipping the score after the dose

The repeat score shows whether the dose worked or precipitated withdrawal. Take it within the hour, before any further dose.

Forgetting the overdose risk

Tolerance falls fast during withdrawal and after a taper, so a usual amount can now be fatal. Give naloxone and teach its use before the patient leaves.

Call out the signs. Review the note.

Vero Scribe records the COWS result in your template from the visit, with the patient’s consent, or from your dictation: the opioid and the time of last use, each sign’s points, the total, the dose given, and when to score again. You review and edit every line, then copy it into your record. Vero works in 60+ languages.

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Frequently asked questions.

How do you score the COWS?

Rate eleven signs: resting pulse, sweating, restlessness, pupil size, bone or joint aches, runny nose or tearing, GI upset, tremor, yawning, anxiety or irritability, and gooseflesh skin. Each scores from 0 up to 4 or 5 points, and the official form describes each level. Add them for a total from 0 to 48. Count a sign only as far as it seems due to opioid withdrawal.

What does a COWS score mean?

A total of 5 to 12 is mild withdrawal, 13 to 24 moderate, 25 to 36 moderately severe, and more than 36 severe. Under 5 is usually read as no active withdrawal. The score shows how severe withdrawal is now, so it changes from hour to hour.

What COWS score do you need to start buprenorphine?

For a standard start, most protocols wait for at least mild to moderate withdrawal, often a COWS of 8 to 12 or more. Many emergency departments use 8; some wait for 13 or more after fentanyl or methadone, when precipitated withdrawal is more likely. Low-dose starts overlap small buprenorphine doses with the current opioid and don’t wait for withdrawal. Follow your own protocol’s threshold.

What is precipitated withdrawal?

Buprenorphine binds to opioid receptors more tightly than full opioids but switches them on less. Given while heroin, fentanyl, or methadone is still active, it can push them off and bring on sudden, severe withdrawal, usually within an hour or two of the dose. On the COWS it shows as a sharp rise after the first dose. Many protocols treat it with more buprenorphine and medicines for the symptoms.

How often should you repeat the COWS?

Before a first buprenorphine dose, then 30 to 60 minutes after each dose until withdrawal settles. On a ward or withdrawal unit, protocols usually repeat it every few hours or each shift while symptoms last. During a taper, once or twice a day is common, and again whenever symptoms change.

How is the COWS different from the SOWS and the CIWA-Ar?

The COWS is rated by a clinician from eleven signs. The SOWS, the Subjective Opiate Withdrawal Scale, has patients rate 16 symptoms themselves from 0 to 4, for a total from 0 to 64; some services use both. The CIWA-Ar does the COWS’s job for alcohol withdrawal.

Who can give the COWS?

Nurses give most COWS assessments, along with physicians, nurse practitioners, physician assistants, pharmacists, paramedics, and trained withdrawal management staff. It takes a few minutes at the bedside. Some services adapt it for video visits, with the patient checking their own pulse.

Is the COWS free to use?

Yes, for patient care. Wesson and Ling appended a version to their 2003 paper for clinicians to copy and use, and many health services and addiction medicine societies post free copies. Get the official form, with the wording for each level, from the paper or your service’s protocol. The recording template on this page is free to copy or download too.

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