Z16 ICD-10-CM Code: Resistance to antimicrobial drugs
Z16 isn’t billable on its own. Choose one of the 19 billable codes beneath it, the one the documentation supports.
Official description
Z16Resistance to antimicrobial drugs
ICD-10-CM diagnosis code · United States clinical modification
Billable codes under Z16
Z16 can’t be reported on its own. Choose the code below that matches what the note documents.
Z16.3 · Resistance to other antimicrobial drugs
Z16.30Resistance to unspecified antimicrobial drugsZ16.31Resistance to antiparasitic drug(s)Z16.32Resistance to antifungal drug(s)Z16.33Resistance to antiviral drug(s)Z16.341Resistance to single antimycobacterial drugZ16.342Resistance to multiple antimycobacterial drugsZ16.35Resistance to multiple antimicrobial drugsZ16.39Resistance to other specified antimicrobial drugWhere Z16 sits
- 1
Chapter 21
Factors influencing health status and contact with health services (Z00-Z99)
- 2
Section
Resistance to antimicrobial drugs (Z16)
- 3
Category Z16
Resistance to antimicrobial drugs
- 4
Code Z16
Resistance to antimicrobial drugs
Notes for this code
Inclusion terms
No inclusion terms are listed for Z16.
Code first
- the infection
Use additional code
No “use additional code” instruction is listed for Z16.
Excludes1
Conditions that should not be reported together with this code.
- Methicillin resistant Staphylococcus aureus infection (A49.02)
- Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
- Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
Excludes2
Conditions not included here that may be reported separately when present.
No Excludes2 note is listed for Z16.
Source and release
- Data release
- U.S. ICD-10-CM · FY 2027
- Effective date
- Oct 1, 2026
- Publisher
- Vero Scribe Inc.
This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.
Frequently asked questions
What does ICD-10-CM code Z16 mean?
Z16 is the FY 2027 U.S. ICD-10-CM code for “Resistance to antimicrobial drugs.”
Is Z16 a billable or specific ICD-10-CM code?
No. Z16 has 19 billable codes beneath it in the FY 2027 reference data. Select the code that matches the documentation and confirm the active code set and payer requirements.
Where is Z16 located in ICD-10-CM?
Z16 is listed in Chapter 21, Factors influencing health status and contact with health services (Z00-Z99), within Resistance to antimicrobial drugs (Z16) (Z16–Z16), under category Z16, Resistance to antimicrobial drugs.
What coding notes are listed for Z16?
No inclusion terms are listed for Z16 in this reference record. Code-first instructions: the infection. Excludes1 notes: Methicillin resistant Staphylococcus aureus infection (A49.02); Methicillin resistant Staphylococcus aureus pneumonia (J15.212); Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02). No Excludes2 note is listed.