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Y53 ICD-10-CA category: Agents primarily affecting the gastrointestinal system

Y53 isn’t a code on its own. Choose one of the 10 codes beneath it, the one the documentation supports.

Official description

Y53

Agents primarily affecting the gastrointestinal system

ICD-10-CA · Canada

Codes in Y53

Y53 isn’t a code on its own. Open the code that matches what the note documents.

Y53.0Histamine H2-receptor antagonists causing adverse effect in therapeutic useY53.1Other antacids and anti-gastric-secretion drugs causing adverse effect in therapeutic useY53.2Stimulant laxatives causing adverse effect in therapeutic useY53.3Saline and osmotic laxatives causing adverse effect in therapeutic useY53.4Other laxatives causing adverse effect in therapeutic useY53.5Digestants causing adverse effect in therapeutic useY53.6Antidiarrhoeal drugs causing adverse effect in therapeutic useY53.7Emetics causing adverse effect in therapeutic useY53.8Other agents primarily affecting the gastrointestinal system causing adverse effect in therapeutic useY53.9Agent primarily affecting the gastrointestinal system, unspecified, causing adverse effect in therapeutic use

Notes for Y53

As CIHI prints them, with any note Y53 takes from the headings above it.

Includes

  • Complications of medical devicescorrect drug properly administered in therapeutic or prophylactic dosage as the cause of any adverse effectmisadventures to patients during surgical and medical caresurgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedureFrom Y40-Y84 Complications of medical and surgical care

Excludes

Conditions classified elsewhere.

Note

  • For list of specific drugs classified under the fourth-character subdivisions, see Table of drugs and chemicals in Alphabetical Index.From Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
  • This chapter, which in previous revisions of ICD constituted a supplementary classification, permits the classification of environmental events and circumstances as the cause of injury, poisoning and other adverse effects. Where a code from this section is applicable, it is intended that it shall be used in addition to a code from another chapter of the Classification indicating the nature of the condition. Most often, the condition will be classifiable to Chapter XIX, Injury, poisoning and certain other consequences of external causes (S00-T98). Causes of death should preferably be tabulated according to both Chapter XIX and Chapter XX, but if only one code is tabulated then the code from Chapter XX should be used in preference. Other conditions that may be stated to be due to external causes are classified in Chapters I to XVIII. For these conditions, codes from Chapter XX should be used to provide additional information for multiple-condition analysis only.From Chapter 20: External causes of morbidity and mortality (V01-Y98)

Where Y53 sits

  1. 1ChapterChapter 20: External causes of morbidity and mortality (V01-Y98)
  2. 2Block Y40-Y84Complications of medical and surgical care
  3. 3Block Y40-Y59Drugs, medicaments and biological substances causing adverse effects in therapeutic use
  4. 4Category Y53Agents primarily affecting the gastrointestinal system

Source and release

Data release
ICD-10-CA · FY 2026–2027
Effective date
Apr 1, 2026
Publisher
CIHI

This page is built from the ICD-10-CA catalog that Vero Codes reads when it suggests codes: Canadian Institute for Health Information’s FY 2026–2027 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.

See Y53 in the CIHI source

Frequently asked questions

Is Y53 a valid ICD-10-CA code?

No. Y53 (Agents primarily affecting the gastrointestinal system) is a category heading in CIHI’s ICD-10-CA FY 2026–2027 release. It holds 10 codes; record the one the documentation supports.

Where is Y53 in ICD-10-CA?

Y53 sits under Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use, within Y40-Y84 Complications of medical and surgical care, within Chapter 20: External causes of morbidity and mortality (V01-Y98).

What coding notes apply to Y53?

ICD-10-CA lists Note, Excludes, Includes notes for Y53, including those from the headings it sits under. They are listed on this page with where each one comes from.

Which ICD-10-CA release does this page use?

It uses CIHI’s FY 2026–2027 release, in effect from Apr 1, 2026 to Mar 31, 2027. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.

Codes beside Y53

Y40Systemic antibioticsY41Other systemic anti-infectives and antiparasiticsY42Hormones and their synthetic substitutes and antagonists, not elsewhere classifiedY43Primarily systemic agentsY44Agents primarily affecting blood constituentsY45Analgesics, antipyretics and anti-inflammatory drugsY46Antiepileptics and antiparkinsonism drugsY47Sedatives, hypnotics and antianxiety drugsY48Anaesthetics and therapeutic gasesY49Psychotropic drugs, not elsewhere classifiedY50Central nervous system stimulants, not elsewhere classifiedY51Drugs primarily affecting the autonomic nervous systemY52Agents primarily affecting the cardiovascular systemY54Agents primarily affecting water-balance and mineral and uric acid metabolismY55Agents primarily acting on smooth and skeletal muscles and the respiratory systemY56Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugsY57Other and unspecified drugs and medicamentsY58Bacterial vaccinesY59Other and unspecified vaccines and biological substances