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Y40-Y59 ICD-10-CA block: Drugs, medicaments and biological substances causing adverse effects in therapeutic use

Y40-Y59 isn’t a code on its own. Choose one of the 184 codes beneath it, the one the documentation supports.

Official description

Y40-Y59

Drugs, medicaments and biological substances causing adverse effects in therapeutic use (Y40-Y59)

ICD-10-CA · Canada

Codes in Y40-Y59

Y40-Y59 isn’t a code on its own. Open the group that matches what the note documents.

Y40Systemic antibiotics (10 codes)Y41Other systemic anti-infectives and antiparasitics (8 codes)Y42Hormones and their synthetic substitutes and antagonists, not elsewhere classified (10 codes)Y43Primarily systemic agents (9 codes)Y44Agents primarily affecting blood constituents (9 codes)Y45Analgesics, antipyretics and anti-inflammatory drugs (14 codes)Y46Antiepileptics and antiparkinsonism drugs (9 codes)Y47Sedatives, hypnotics and antianxiety drugs (8 codes)Y48Anaesthetics and therapeutic gases (6 codes)Y49Psychotropic drugs, not elsewhere classified (13 codes)Y50Central nervous system stimulants, not elsewhere classified (5 codes)Y51Drugs primarily affecting the autonomic nervous system (10 codes)Y52Agents primarily affecting the cardiovascular system (10 codes)Y53Agents primarily affecting the gastrointestinal system (10 codes)Y54Agents primarily affecting water-balance and mineral and uric acid metabolism (10 codes)Y55Agents primarily acting on smooth and skeletal muscles and the respiratory system (8 codes)Y56Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs (10 codes)Y57Other and unspecified drugs and medicaments (10 codes)Y58Bacterial vaccines (9 codes)Y59Other and unspecified vaccines and biological substances (6 codes)

Notes for Y40-Y59

As CIHI prints them, with any note Y40-Y59 takes from the headings above it.

Includes

  • Complications of medical devicescorrect drug properly administered in therapeutic or prophylactic dosage as the cause of any adverse effectmisadventures to patients during surgical and medical caresurgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedureFrom Y40-Y84 Complications of medical and surgical care

Excludes

Conditions classified elsewhere.

  • Accidents in the technique of administration of drugs, medicaments and biological substances in medical and surgical procedures (Y60-Y69)
  • Accidental overdose of drug or wrong drug given or taken in error (X40-X44)From Y40-Y84 Complications of medical and surgical care

Note

  • For list of specific drugs classified under the fourth-character subdivisions, see Table of drugs and chemicals in Alphabetical Index.
  • This chapter, which in previous revisions of ICD constituted a supplementary classification, permits the classification of environmental events and circumstances as the cause of injury, poisoning and other adverse effects. Where a code from this section is applicable, it is intended that it shall be used in addition to a code from another chapter of the Classification indicating the nature of the condition. Most often, the condition will be classifiable to Chapter XIX, Injury, poisoning and certain other consequences of external causes (S00-T98). Causes of death should preferably be tabulated according to both Chapter XIX and Chapter XX, but if only one code is tabulated then the code from Chapter XX should be used in preference. Other conditions that may be stated to be due to external causes are classified in Chapters I to XVIII. For these conditions, codes from Chapter XX should be used to provide additional information for multiple-condition analysis only.From Chapter 20: External causes of morbidity and mortality (V01-Y98)

Where Y40-Y59 sits

  1. 1ChapterChapter 20: External causes of morbidity and mortality (V01-Y98)
  2. 2Block Y40-Y84Complications of medical and surgical care
  3. 3Block Y40-Y59Drugs, medicaments and biological substances causing adverse effects in therapeutic use

Source and release

Data release
ICD-10-CA · FY 2026–2027
Effective date
Apr 1, 2026
Publisher
CIHI

This page is built from the ICD-10-CA catalog that Vero Codes reads when it suggests codes: Canadian Institute for Health Information’s FY 2026–2027 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.

See Y40-Y59 in the CIHI source

Frequently asked questions

Is Y40-Y59 a valid ICD-10-CA code?

No. Y40-Y59 (Drugs, medicaments and biological substances causing adverse effects in therapeutic use) is a block heading in CIHI’s ICD-10-CA FY 2026–2027 release. It holds 184 codes; record the one the documentation supports.

Where is Y40-Y59 in ICD-10-CA?

Y40-Y59 sits under Y40-Y84 Complications of medical and surgical care, within Chapter 20: External causes of morbidity and mortality (V01-Y98).

What coding notes apply to Y40-Y59?

ICD-10-CA lists Note, Excludes, Includes notes for Y40-Y59, including those from the headings it sits under. They are listed on this page with where each one comes from.

Which ICD-10-CA release does this page use?

It uses CIHI’s FY 2026–2027 release, in effect from Apr 1, 2026 to Mar 31, 2027. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.

Codes beside Y40-Y59

Y60-Y69Misadventures to patients during surgical and medical careY70-Y82Medical devices associated with adverse incidents in diagnostic and therapeutic useY83-Y84Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure