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Y43 ICD-10-CA category: Primarily systemic agents

Y43 isn’t a code on its own. Choose one of the 9 codes beneath it, the one the documentation supports.

Official description

Y43

Primarily systemic agents

ICD-10-CA · Canada

Codes in Y43

Y43 isn’t a code on its own. Open the code that matches what the note documents.

Y43.0Antiallergic and antiemetic drugs causing adverse effect in therapeutic useY43.1Antineoplastic antimetabolites causing adverse effect in therapeutic useY43.2Antineoplastic natural products causing adverse effect in therapeutic useY43.3Other antineoplastic drugs causing adverse effect in therapeutic useY43.4Immunosuppressive agents causing adverse effect in therapeutic useY43.5Acidifying and alkalizing agents causing adverse effect in therapeutic useY43.6Enzymes, not elsewhere classified, causing adverse effect in therapeutic useY43.8Other primarily systemic agents, not elsewhere classified, causing adverse effect in therapeutic useY43.9Primarily systemic agent, unspecified, causing adverse effect in therapeutic use

Notes for Y43

As CIHI prints them, with any note Y43 takes from the headings above it.

Includes

  • Complications of medical devicescorrect drug properly administered in therapeutic or prophylactic dosage as the cause of any adverse effectmisadventures to patients during surgical and medical caresurgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedureFrom Y40-Y84 Complications of medical and surgical care

Excludes

Conditions classified elsewhere.

Note

  • For list of specific drugs classified under the fourth-character subdivisions, see Table of drugs and chemicals in Alphabetical Index.From Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
  • This chapter, which in previous revisions of ICD constituted a supplementary classification, permits the classification of environmental events and circumstances as the cause of injury, poisoning and other adverse effects. Where a code from this section is applicable, it is intended that it shall be used in addition to a code from another chapter of the Classification indicating the nature of the condition. Most often, the condition will be classifiable to Chapter XIX, Injury, poisoning and certain other consequences of external causes (S00-T98). Causes of death should preferably be tabulated according to both Chapter XIX and Chapter XX, but if only one code is tabulated then the code from Chapter XX should be used in preference. Other conditions that may be stated to be due to external causes are classified in Chapters I to XVIII. For these conditions, codes from Chapter XX should be used to provide additional information for multiple-condition analysis only.From Chapter 20: External causes of morbidity and mortality (V01-Y98)

Where Y43 sits

  1. 1ChapterChapter 20: External causes of morbidity and mortality (V01-Y98)
  2. 2Block Y40-Y84Complications of medical and surgical care
  3. 3Block Y40-Y59Drugs, medicaments and biological substances causing adverse effects in therapeutic use
  4. 4Category Y43Primarily systemic agents

Source and release

Data release
ICD-10-CA · FY 2026–2027
Effective date
Apr 1, 2026
Publisher
CIHI

This page is built from the ICD-10-CA catalog that Vero Codes reads when it suggests codes: Canadian Institute for Health Information’s FY 2026–2027 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.

See Y43 in the CIHI source

Frequently asked questions

Is Y43 a valid ICD-10-CA code?

No. Y43 (Primarily systemic agents) is a category heading in CIHI’s ICD-10-CA FY 2026–2027 release. It holds 9 codes; record the one the documentation supports.

Where is Y43 in ICD-10-CA?

Y43 sits under Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use, within Y40-Y84 Complications of medical and surgical care, within Chapter 20: External causes of morbidity and mortality (V01-Y98).

What coding notes apply to Y43?

ICD-10-CA lists Excludes, Note, Includes notes for Y43, including those from the headings it sits under. They are listed on this page with where each one comes from.

Which ICD-10-CA release does this page use?

It uses CIHI’s FY 2026–2027 release, in effect from Apr 1, 2026 to Mar 31, 2027. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.

Codes beside Y43

Y40Systemic antibioticsY41Other systemic anti-infectives and antiparasiticsY42Hormones and their synthetic substitutes and antagonists, not elsewhere classifiedY44Agents primarily affecting blood constituentsY45Analgesics, antipyretics and anti-inflammatory drugsY46Antiepileptics and antiparkinsonism drugsY47Sedatives, hypnotics and antianxiety drugsY48Anaesthetics and therapeutic gasesY49Psychotropic drugs, not elsewhere classifiedY50Central nervous system stimulants, not elsewhere classifiedY51Drugs primarily affecting the autonomic nervous systemY52Agents primarily affecting the cardiovascular systemY53Agents primarily affecting the gastrointestinal systemY54Agents primarily affecting water-balance and mineral and uric acid metabolismY55Agents primarily acting on smooth and skeletal muscles and the respiratory systemY56Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugsY57Other and unspecified drugs and medicamentsY58Bacterial vaccinesY59Other and unspecified vaccines and biological substances