U.S. ICD-10-CM · FY 2027

Z21 ICD-10-CM Code: Asymptomatic human immunodeficiency virus [HIV] infection status

A clear reference for the official code description, hierarchy, and related coding information from the FY 2027 U.S. release.

Code definition

Official description

Z21

Asymptomatic human immunodeficiency virus [HIV] infection status

ICD-10-CM diagnosis code · United States clinical modification

Classification

Where Z21 sits

  1. 1

    Chapter 21

    Factors influencing health status and contact with health services (Z00-Z99)

  2. 2

    Section

    Persons with potential health hazards related to communicable diseases (Z20-Z29)

  3. 3

    Category Z21

    Asymptomatic human immunodeficiency virus [HIV] infection status

  4. 4

    Code Z21

    Asymptomatic human immunodeficiency virus [HIV] infection status

Documentation details

Notes for this code

Inclusion terms

  • HIV positive NOS

Code first

  • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)

Use additional code

No “use additional code” instruction is listed for Z21.

Excludes1

Conditions that should not be reported together with this code.

  • acquired immunodeficiency syndrome (B20)
  • contact with human immunodeficiency virus [HIV] (Z20.6)
  • exposure to human immunodeficiency virus [HIV] (Z20.6)
  • human immunodeficiency virus [HIV] disease (B20)
  • inconclusive laboratory evidence of human immunodeficiency virus [HIV] (R75)

Excludes2

Conditions not included here that may be reported separately when present.

No Excludes2 note is listed for Z21.

Transparency

Source and release

Data release

U.S. ICD-10-CM · FY 2027

Effective date

Oct 1, 2026

Publisher

Vero Scribe Inc.

This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.

Review the CDC/NCHS ICD-10-CM source

Code-specific guidance

Frequently asked questions

What does ICD-10-CM code Z21 mean?

Z21 is the FY 2027 U.S. ICD-10-CM code for “Asymptomatic human immunodeficiency virus [HIV] infection status.”

Is Z21 a billable or specific ICD-10-CM code?

Yes. In the FY 2027 reference data used on this page, Z21 has no child codes and is presented as a billable/specific code. Always confirm the active code set and payer requirements before use.

Where is Z21 located in ICD-10-CM?

Z21 is listed in Chapter 21, Factors influencing health status and contact with health services (Z00-Z99), within Persons with potential health hazards related to communicable diseases (Z20-Z29) (Z20–Z29), under category Z21, Asymptomatic human immunodeficiency virus [HIV] infection status.

What coding notes are listed for Z21?

Its listed inclusion terms are HIV positive NOS. Code-first instructions: Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-). Excludes1 notes: acquired immunodeficiency syndrome (B20); contact with human immunodeficiency virus [HIV] (Z20.6); exposure to human immunodeficiency virus [HIV] (Z20.6); human immunodeficiency virus [HIV] disease (B20); inconclusive laboratory evidence of human immunodeficiency virus [HIV] (R75). No Excludes2 note is listed.

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