C49 ICD-10-CM Code: Malignant neoplasm of other connective and soft tissue
A clear reference for the official code description, hierarchy, and related coding information from the April 2026 U.S. release.
Code definition
Official description
C49Malignant neoplasm of other connective and soft tissue
ICD-10-CM diagnosis code · United States clinical modification
Classification
Where C49 sits
- 1
Chapter 2
Neoplasms (C00-D49)
- 2
Section
Malignant neoplasms of mesothelial and soft tissue (C45-C49)
- 3
Category C49
Malignant neoplasm of other connective and soft tissue
- 4
Code C49
Malignant neoplasm of other connective and soft tissue
More specific choices
Codes under C49
C49 is a non-billable category. Choose the child code that best matches the documented diagnosis.
C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
C49.1Malignant neoplasm of connective and soft tissue of upper limb, including shoulder
C49.2Malignant neoplasm of connective and soft tissue of lower limb, including hip
C49.3Malignant neoplasm of connective and soft tissue of thorax
C49.4Malignant neoplasm of connective and soft tissue of abdomen
C49.5Malignant neoplasm of connective and soft tissue of pelvis
C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
C49.9Malignant neoplasm of connective and soft tissue, unspecified
C49.AGastrointestinal stromal tumor
Documentation details
Notes for this code
Inclusion terms
No inclusion terms are listed for C49.
Code first
No “code first” instruction is listed for C49.
Use additional code
No “use additional code” instruction is listed for C49.
Excludes1
Conditions that should not be reported together with this code.
- malignant neoplasm of cartilage (of):
- articular (C40-C41)
- larynx (C32.3)
- nose (C30.0)
- malignant neoplasm of connective tissue of breast (C50.-)
Excludes2
Conditions not included here that may be reported separately when present.
- Kaposi's sarcoma of soft tissue (C46.1)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- malignant neoplasm of peritoneum (C48.2)
- malignant neoplasm of retroperitoneum (C48.0)
- malignant neoplasm of uterine ligament (C57.3)
- mesothelioma (C45.-)
Transparency
Source and release
This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.
Review the CDC/NCHS ICD-10-CM sourceCode-specific guidance
Frequently asked questions
What does ICD-10-CM code C49 mean?
C49 is the April 2026 U.S. ICD-10-CM code for “Malignant neoplasm of other connective and soft tissue.”
Is C49 a billable or specific ICD-10-CM code?
No. C49 has more specific child codes in the April 2026 reference data. Select the code that matches the documentation and confirm the active code set and payer requirements.
Where is C49 located in ICD-10-CM?
C49 is listed in Chapter 2, Neoplasms (C00-D49), within Malignant neoplasms of mesothelial and soft tissue (C45-C49) (C45–C49), under category C49, Malignant neoplasm of other connective and soft tissue.
What coding notes are listed for C49?
No inclusion terms are listed for C49 in this reference record. No code-first instruction is listed. Excludes1 notes: malignant neoplasm of cartilage (of):; articular (C40-C41); larynx (C32.3); nose (C30.0); malignant neoplasm of connective tissue of breast (C50.-). Excludes2 notes: Kaposi's sarcoma of soft tissue (C46.1); malignant neoplasm of heart (C38.0); malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-); malignant neoplasm of peritoneum (C48.2); malignant neoplasm of retroperitoneum (C48.0); malignant neoplasm of uterine ligament (C57.3); mesothelioma (C45.-).
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