Treatment evidence, option by option.

Ask what to start, or what comes next. Vero lays out each option with its effect, the trials behind it, and the guideline’s line, with every source linked.

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Postmenopausal osteoporosis. Which drug first?

Weighing the options

First-line pubmedL1Bisphosphonate, such as alendronateNew vertebral fractures 8% vs 15% on placebo
Second-line pubmedL1Denosumab68% fewer vertebral fractures than placebo
Very high risk pubmedL1Romosozumab, then alendronate48% fewer vertebral fractures than alendronate alone

Start a bisphosphonate. Denosumab second-line; romosozumab or teriparatide first only at very high risk. acpjournals

Ask what comes next. Pick a condition.

Acute gout flare

What to start for a gout flare

The rheumatology guideline, and the trial that settled the colchicine dose.

Acute gout flare. What do I start?

First-lineColchicine, an NSAID, or a glucocorticoidAll three strongly recommended; choose by comorbidity rheumatology
If colchicineLow dose: 1.8 mg over 1 hourRelief like 4.8 mg, with diarrhea in 23% vs 77% rheumatology pubmedL1
If those don’t suitAn IL-1 inhibitorConditionally recommended rheumatology

Topical ice is suggested as an add-on. rheumatology

2020 American College of Rheumatology guideline for the management of goutClinical guideline · ACR 2020rheumatology
High versus low dosing of oral colchicine for early acute gout flare: twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine studyRandomized trial · 184 patientspubmedL1

Chronic insomnia. Pills or CBT-I first?

First-lineCBT-I, for every adultAsleep 19 minutes sooner, 26 fewer minutes awake at night acpjournals pubmedL1
If CBT-I alone failsShort-term medicationDecided together: benefits, harms, and cost acpjournals

Sleep efficiency rose by about 10 points, with no harms reported. pubmedL1

Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of PhysiciansClinical guideline · ACP 2016acpjournals
Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysisMeta-analysis · 20 trials, 1,162 patientspubmedL1

Knee osteoarthritis pain. What comes first?

CoreExercise, with weight managementPain down about 12 points out of 100 oarsijournal pubmedL1
AddA topical NSAIDStrongly recommended for knee OA oarsijournal
AvoidOral or transdermal opioidsStrongly not recommended oarsijournal

Acetaminophen is conditionally not recommended. oarsijournal

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritisClinical guideline · OARSI 2019oarsijournal
Exercise for osteoarthritis of the kneeCochrane review · 54 trialspubmedL1

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Options side by side, the way Vero writes them.

Ask for a comparison. Each option arrives with its trial, its effect, and what to watch for.

Minor stroke, NIHSS 2, seen at 6 hours. Compare antiplatelet options in a table.

Aspirin + clopidogrel21 to 90 days, then one agentDoesStroke at 90 days: 8.2% vs 11.7% on aspirin alonepubmedL1CHANCEWatchMajor bleeding 0.9% vs 0.4% when given for 90 days pubmedL1

Aspirin + ticagrelor30 days, then one agentDoesStroke or death at 30 days: 5.5% vs 6.6%pubmedL1THALESWatchSevere bleeding 0.5% vs 0.1%

Dual therapy long termYears, after a lacunar strokeDoesNo fewer strokes: 2.5% vs 2.7% a yearpubmedL1SPS3WatchMajor bleeding 2.1% vs 1.1% a year, and more deaths

AHA/ASA: aspirin plus clopidogrel, started early, for 21 to 90 days, then one antiplatelet. ahajournals

Numbers that matter, worked from the trial.

Absolute risk, not only relative. Ask for the NNT and see the event rates it comes from.

Work out an NNT free

Options for this patient, and for your clinic.

Narrowed to the patient

Attach a patient, and options that clash with an allergy, a medication, or the history drop out, with the reason given.

Your protocol beside the guideline

Add clinic protocols and formularies to a library the whole team shares. Answers name the document they draw on.

Explore Vero Evidence

Patient privacy, built in from the start.

Every visit is protected health information, and Vero handles it that way from the first word to the final note.

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Audited compliance

SOC 2 Type II certified. HIPAA compliant.

No audio kept

Recordings are used to write the note and are never stored.

Never used for training

Your patients’ data is never used to train AI models.

Your retention rules

Notes auto-delete after 1 to 365 days, on your schedule. Multi‑factor sign-in included.

Questions about treatment evidence.

What is treatment evidence?

The guidelines, trials, and reviews behind each option for a condition. Vero brings them into one answer and links every source.

Can Vero compare treatment options side by side?

Yes. Ask for a comparison table, and Vero writes one: what each option does, the evidence for it, and what to watch for, each cited.

Does Vero give absolute risk reduction and NNT?

Ask for them. Vero works them out from the event rates the trial reported and cites the trial, so you can check every input.

How strong is the evidence behind an option?

Each trial source is graded, from L1 (systematic reviews and randomized trials) down to L4 (expert opinion), with cohort studies at L2 and case-control studies or case series at L3. Guidelines are not graded.

Will the options fit my patient?

Attach the patient. Vero accounts for their allergies, medications, history, and past visits on file, and says which options drop out and why.

Can I get Canadian or US guidance?

Add your location when jurisdiction matters, and Vero weighs the guidelines that apply where you work, such as Osteoporosis Canada or the ACP.

What if the evidence is thin or conflicting?

Vero says so, with the sources on each side, instead of forcing a single answer.

Does it cost anything?

Vero Evidence comes with every plan. Free gives you 10 actions a month with no credit card; Pro removes the limit.

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After the treatment question, more of Vero Evidence.

Diagnostic evidence

Test accuracy and decision rules, cited.

Check diagnostic evidence

Contextual evidence

Answers that account for the patient in front of you.

See contextual evidence

Clinical guideline search

The current recommendation, from the body that issued it.

Search clinical guidelines

Source comparison

Where the guidelines agree, and where they differ.

Compare sources

Weigh the next option with its evidence in view.

Guidelines, trials, and harms for each choice, cited and graded.

Compare treatments free

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