Source comparison: where the guidelines agree, and where they don’t.

Ask how the sources differ on one question. Vero lines the guidelines and studies up side by side, and cites every position.

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Same question, different guidelines.

LDL-C goals

LDL-C in very-high-risk ASCVD

A goal in one guideline, a threshold for adding therapy in another.

Aspirin for primary prevention: US and Canada?

USPSTFUnited States

IndividualAge 40 to 59 at 10% risk or more: Grade C. Not from 60: Grade D.

uspreventiveservicestaskforce

CCS/CAICCanada

Not routineRecommends against routine aspirin for primary prevention.

onlinecjc

Both advise against routine aspirin to prevent a first event. uspreventiveservicestaskforce onlinecjc

USPSTF leaves an individual decision at 40 to 59 with a 10% risk or more, and advises against starting at 60 or older. uspreventiveservicestaskforce

Compare your own sources

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One topic, point by point.

Ask for a table, and the guidelines line up point by point, each one cited.

Compare the hypertension guidelines in a table.

Hypertension guidelines compared point by point: AHA/ACC 2025, ESC 2024, NICE NG136. Rows: where hypertension starts, when drugs start, the target, first-line drug classes, and how treatment starts.
Point	AHA/ACC 2025ahajournals	ESC 2024escardio	NICE NG136nice
Hypertension fromThey differ	130/80	140/90; 120 to 139 over 70 to 89 is “elevated”	140/90 in clinic, confirmed at 135/85 or more on ABPM or home readings
Drugs start atThey differ	130/80 with CVD, diabetes, CKD, or 10-year risk of 7.5% or more; others after 3 to 6 months of lifestyle change	140/90 for all; 130/80 at high risk after 3 months of lifestyle change	Stage 2 at any age. Stage 1 under 80: discuss with organ damage, CVD, renal disease, diabetes, or 10-year risk of 10% or more
Treat toThey differ	Below 130/80, with below 120 systolic encouraged	Systolic 120 to 129, if tolerated	Below 140/90 under 80; below 150/90 from 80Differs
First-line classesAll agree	ACE inhibitor or ARB, CCB, thiazide	ACE inhibitor or ARB, dihydropyridine CCB, thiazide or thiazide-like	ACE inhibitor or ARB, or a CCB; thiazide-like if a CCB doesn’t suit
Start withThey differ	Two drugs in one pill at stage 2, 140/90 or more	Two low-dose drugs, ideally in one pill, for most	One drug, chosen by age, type 2 diabetes, and family originDiffers

They agree on the drug classes. They differ on where hypertension starts, the target, and whether to start with one drug or two. ahajournals escardio nice

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When the studies disagree.

Vero says when the evidence conflicts, with source-backed caveats, and each study carries its level of evidence.

Do vitamin D supplements prevent heart disease?

L1Meta-analysis · 21 trials, 83,291 peopleRR 1.00Major cardiovascular events with supplementsVitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis

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L2Cohort study · 1,739 peopleHR 1.62First cardiovascular event, vitamin D below 15 ng/mLVitamin D deficiency and risk of cardiovascular disease

The studies conflict. In a cohort, vitamin D below 15 ng/mL came with a 62% higher risk of a first cardiovascular event. pubmedL2

Across 21 trials, supplements did not lower major cardiovascular events. The trials outweigh an association that may be confounded. pubmedL1

Your protocol against the guideline

Upload your clinic’s protocol and the national guideline, or keep both in your Library, and ask where they part. The answer names both documents.

Explore Vero Evidence

Source comparison, answered.

What is source comparison?

Putting the same clinical question to several guidelines or studies and seeing where they agree and where they differ. Vero sets out each source’s position and cites every one.

How do I compare guidelines in Vero?

Ask in plain words, such as “How do ESC and NICE differ on BP targets?” The answer gives each source’s position with its citation, and Vero can lay it out as a table when you ask for one.

Can I compare my clinic’s protocol with a guideline?

Yes. Upload both, or add them to your Library, and ask where they differ. The answer names both documents.

What happens when studies disagree?

Vero says when evidence conflicts or is limited, with source-backed caveats. Trial literature carries its level of evidence, L1 to L4, so you can see which study weighs more.

Why do guidelines disagree?

They weigh the same trials differently, draw the line between benefit and harm in different places, and are written for different health systems and in different years.

Does Vero include Canadian guidelines?

Yes. Say where you practise when jurisdiction matters, and Vero weighs the guidelines that apply there, Canadian or US.

Is source comparison free?

Vero Evidence is included in every plan. The free plan comes with 10 actions a month and needs no credit card; Pro is unlimited.

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