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Y45.9 ICD-10-CA code: Analgesic, antipyretic and anti-inflammatory drug, unspecified, causing adverse effect in therapeutic use

Y45.9 is the ICD-10-CA code for “Analgesic, antipyretic and anti-inflammatory drug, unspecified, causing adverse effect in therapeutic use” in CIHI’s FY 2026–2027 release, in effect from Apr 1, 2026.

Official description

Y45.9

Analgesic, antipyretic and anti-inflammatory drug, unspecified, causing adverse effect in therapeutic use

Short description: Anlgsc antipyr dr NOS adv eff Rx use

ICD-10-CA · Canada · Also written Y459

Notes for Y45.9

As CIHI prints them, with any note Y45.9 takes from the headings above it.

Includes

  • Complications of medical devicescorrect drug properly administered in therapeutic or prophylactic dosage as the cause of any adverse effectmisadventures to patients during surgical and medical caresurgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedureFrom Y40-Y84 Complications of medical and surgical care

Excludes

Conditions classified elsewhere.

Note

  • For list of specific drugs classified under the fourth-character subdivisions, see Table of drugs and chemicals in Alphabetical Index.From Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
  • This chapter, which in previous revisions of ICD constituted a supplementary classification, permits the classification of environmental events and circumstances as the cause of injury, poisoning and other adverse effects. Where a code from this section is applicable, it is intended that it shall be used in addition to a code from another chapter of the Classification indicating the nature of the condition. Most often, the condition will be classifiable to Chapter XIX, Injury, poisoning and certain other consequences of external causes (S00-T98). Causes of death should preferably be tabulated according to both Chapter XIX and Chapter XX, but if only one code is tabulated then the code from Chapter XX should be used in preference. Other conditions that may be stated to be due to external causes are classified in Chapters I to XVIII. For these conditions, codes from Chapter XX should be used to provide additional information for multiple-condition analysis only.From Chapter 20: External causes of morbidity and mortality (V01-Y98)

Where Y45.9 sits

  1. 1ChapterChapter 20: External causes of morbidity and mortality (V01-Y98)
  2. 2Block Y40-Y84Complications of medical and surgical care
  3. 3Block Y40-Y59Drugs, medicaments and biological substances causing adverse effects in therapeutic use
  4. 4Category Y45Analgesics, antipyretics and anti-inflammatory drugs
  5. 5Valid code Y45.9Analgesic, antipyretic and anti-inflammatory drug, unspecified, causing adverse effect in therapeutic use

Source and release

Data release
ICD-10-CA · FY 2026–2027
Effective date
Apr 1, 2026
Publisher
CIHI

This page is built from the ICD-10-CA catalog that Vero Codes reads when it suggests codes: Canadian Institute for Health Information’s FY 2026–2027 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.

See Y45.9 in the CIHI source

Frequently asked questions

What does ICD-10-CA code Y45.9 mean?

Y45.9 is the ICD-10-CA code for “Analgesic, antipyretic and anti-inflammatory drug, unspecified, causing adverse effect in therapeutic use” in CIHI’s ICD-10-CA FY 2026–2027 release.

Where is Y45.9 in ICD-10-CA?

Y45.9 sits under Y45 Analgesics, antipyretics and anti-inflammatory drugs, within Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use, within Y40-Y84 Complications of medical and surgical care, within Chapter 20: External causes of morbidity and mortality (V01-Y98).

What coding notes apply to Y45.9?

ICD-10-CA lists Note, Excludes, Includes notes for Y45.9, including those from the headings it sits under. They are listed on this page with where each one comes from.

Which ICD-10-CA release does this page use?

It uses CIHI’s FY 2026–2027 release, in effect from Apr 1, 2026 to Mar 31, 2027. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.

Codes beside Y45.9

Y45.0Opioids and related analgesicsY45.1Salicylates causing adverse effect in therapeutic useY45.2Propionic acid derivatives causing adverse effect in therapeutic useY45.3Other nonsteroidal anti-inflammatory drugs [NSAID] causing adverse effect in therapeutic useY45.4Antirheumatics causing adverse effect in therapeutic useY45.54-Aminophenol derivatives causing adverse effect in therapeutic useY45.8Other analgesics and antipyretics causing adverse effect in therapeutic use