D81 ICD-10-CA category: Combined immunodeficiencies
D81 isn’t a code on its own. Choose one of the 10 codes beneath it, the one the documentation supports.
Official description
D81Combined immunodeficiencies
ICD-10-CA · Canada
Codes in D81
D81 isn’t a code on its own. Open the code that matches what the note documents.
D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesisD81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbersD81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbersD81.3Adenosine deaminase [ADA] deficiencyD81.4Nezelof's syndromeD81.5Purine nucleoside phosphorylase [PNP] deficiencyD81.6Major histocompatibility complex class I deficiencyD81.7Major histocompatibility complex class II deficiencyD81.8Other combined immunodeficienciesD81.9Combined immunodeficiency, unspecifiedNotes for D81
As CIHI prints them, with any note D81 takes from the headings above it.
Includes
- Defects in the complement systemimmunodeficiency disorders, except human immunodeficiency virus [HIV] diseasesarcoidosisFrom D80-D89 Certain disorders involving the immune mechanism
Excludes
Conditions classified elsewhere.
- Autosomal recessive agammaglobulinaemia (Swiss type) (D80.0)
- Autoimmune disease (systemic) NOS (M35.9)functional disorders of polymorphonuclear neutrophils (D71)human immunodeficiency virus [HIV] disease (B24)human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium (O98.7-)From D80-D89 Certain disorders involving the immune mechanism
- Autoimmune disease (systemic) NOS (M35.9)certain conditions originating in the perinatal period (P00-P96)complications of pregnancy, childbirth and the puerperium (O00-O99)congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)endocrine, nutritional and metabolic diseases (E00-E90)human immunodeficiency virus [HIV] disease (B24)injury, poisoning and certain other consequences of external causes (S00-T98)neoplasms (C00-D48)symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)From Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Where D81 sits
- 1ChapterChapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- 2Block D80-D89Certain disorders involving the immune mechanism
- 3Category D81Combined immunodeficiencies
Source and release
- Data release
- ICD-10-CA · FY 2026–2027
- Effective date
- Apr 1, 2026
- Publisher
- CIHI
This page is built from the ICD-10-CA catalog that Vero Codes reads when it suggests codes: Canadian Institute for Health Information’s FY 2026–2027 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.
Frequently asked questions
Is D81 a valid ICD-10-CA code?
No. D81 (Combined immunodeficiencies) is a category heading in CIHI’s ICD-10-CA FY 2026–2027 release. It holds 10 codes; record the one the documentation supports.
Where is D81 in ICD-10-CA?
D81 sits under D80-D89 Certain disorders involving the immune mechanism, within Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).
What coding notes apply to D81?
ICD-10-CA lists Excludes, Includes notes for D81, including those from the headings it sits under. They are listed on this page with where each one comes from.
Which ICD-10-CA release does this page use?
It uses CIHI’s FY 2026–2027 release, in effect from Apr 1, 2026 to Mar 31, 2027. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.