S5521 HCPCS Level II code: Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion
S5521 is the HCPCS code for “Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion” in CMS’s October 2026 release, in effect from Oct 1, 2026.
Official description
S5521Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion
Short description: Hit midline cath insert kit
HCPCS · United States
Notes for S5521
As CMS prints them, with any note S5521 takes from the headings above it.
Note
- CMS processing note 0088: "S" CODES ARE UNIQUE TEMPORARY CODES ESTABLISHED BY BCBSA AND HIAA FOR PRIVATE PAYOR USE. THEY ARE NOT VALID NOR PAYABLE BY MEDICARE.
Medicare details
The indicators CMS publishes with S5521 in its October 2026 file. They describe Medicare’s handling, not another payer’s.
- Medicare coverage
- Not payable by Medicare
- Medicare pricing
- Service not separately priced by Part B (e.g., services not covered, bundled, used by Part A only, etc.)
- Type of service
- Other medical items or services
- BETOS category
- Undefined codes
- Added
- Jan 1, 2002
Where S5521 sits
- 1S codesTemporary national codes (non-Medicare)
- 2Active code S5521Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion
Source and release
- Data release
- HCPCS Level II · October 2026
- Effective date
- Oct 1, 2026
- Publisher
- CMS
This page is built from the HCPCS Level II catalog that Vero Codes reads when it suggests codes: Centers for Medicare & Medicaid Services’s October 2026 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.
Frequently asked questions
What does HCPCS code S5521 mean?
S5521 is the HCPCS code for “Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion” in CMS’s HCPCS Level II October 2026 release.
Does Medicare cover S5521?
CMS lists S5521’s Medicare coverage as “Not payable by Medicare” and its pricing as “Service not separately priced by Part B (e.g., services not covered, bundled, used by Part A only, etc.)”. Coverage and payment still depend on the patient, the setting, the documentation and the payer.
Which HCPCS Level II release does this page use?
It uses CMS’s October 2026 release, in effect from Oct 1, 2026 to Dec 31, 2026. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.
Codes beside S5521
All S codesS5498Home infusion therapy, catheter care / maintenance, simple (single lumen), includes administrative services, professional pharmacy services, care coordination and all necessary…S5501Home infusion therapy, catheter care / maintenance, complex (more than one lumen), includes administrative services, professional pharmacy services, care coordination, and all…S5502Home infusion therapy, catheter care / maintenance, implanted access device, includes administrative services, professional pharmacy services, care coordination and all necessary…S5517Home infusion therapy, all supplies necessary for restoration of catheter patency or declottingS5518Home infusion therapy, all supplies necessary for catheter repairS5520Home infusion therapy, all supplies (including catheter) necessary for a peripherally inserted central venous catheter (picc) line insertionS5522Home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included)S5523Home infusion therapy, insertion of midline venous catheter, nursing services only (no supplies or catheter included)S5550Insulin, rapid onset, 5 unitsS5551Insulin, most rapid onset (lispro or aspart); 5 unitsS5552Insulin, intermediate acting (nph or lente); 5 unitsS5553Insulin, long acting; 5 units