J0456 HCPCS Level II code: Injection, azithromycin, 500 mg

J0456 is the HCPCS code for “Injection, azithromycin, 500 mg” in CMS’s October 2026 release, in effect from Oct 1, 2026.

Official description

J0456

Injection, azithromycin, 500 mg

Short description: Azithromycin

HCPCS · United States

Medicare details

The indicators CMS publishes with J0456 in its October 2026 file. They describe Medicare’s handling, not another payer’s.

Medicare coverage
Special coverage instructions apply
Medicare pricing
Drugs
Type of service
Medical care; Lump sum purchase of DME, prosthetics, orthotics
BETOS category
Other drugs
Added
Jan 1, 2000

Where J0456 sits

  1. 1J codesDrugs administered other than orally
  2. 2Active code J0456Injection, azithromycin, 500 mg

Source and release

Data release
HCPCS Level II · October 2026
Effective date
Oct 1, 2026
Publisher
CMS

This page is built from the HCPCS Level II catalog that Vero Codes reads when it suggests codes: Centers for Medicare & Medicaid Services’s October 2026 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.

Frequently asked questions

What does HCPCS code J0456 mean?

J0456 is the HCPCS code for “Injection, azithromycin, 500 mg” in CMS’s HCPCS Level II October 2026 release.

Does Medicare cover J0456?

CMS lists J0456’s Medicare coverage as “Special coverage instructions apply” and its pricing as “Drugs”. Coverage and payment still depend on the patient, the setting, the documentation and the payer.

Which HCPCS Level II release does this page use?

It uses CMS’s October 2026 release, in effect from Oct 1, 2026 to Dec 31, 2026. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.