A4221 HCPCS Level II code: Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)
A4221 is the HCPCS code for “Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)” in CMS’s October 2026 release, in effect from Oct 1, 2026.
Official description
A4221Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)
Short description: Supp non-insulin inf cath/wk
HCPCS · United States
Medicare details
The indicators CMS publishes with A4221 in its October 2026 file. They describe Medicare’s handling, not another payer’s.
- Medicare coverage
- Carrier judgment
- Medicare pricing
- DMEPOS fee schedule – DME supplies (price subject to floors and ceilings)
- Type of service
- Lump sum purchase of DME, prosthetics, orthotics
- BETOS category
- Other DME
- Added
- Jan 1, 1997
Where A4221 sits
- 1A codesAmbulance, supplies and miscellaneous
- 2Active code A4221Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)
Source and release
- Data release
- HCPCS Level II · October 2026
- Effective date
- Oct 1, 2026
- Publisher
- CMS
This page is built from the HCPCS Level II catalog that Vero Codes reads when it suggests codes: Centers for Medicare & Medicaid Services’s October 2026 release, imported from the publisher’s file and checked against it. The description, notes and structured data come from the same record.
Frequently asked questions
What does HCPCS code A4221 mean?
A4221 is the HCPCS code for “Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)” in CMS’s HCPCS Level II October 2026 release.
Does Medicare cover A4221?
CMS lists A4221’s Medicare coverage as “Carrier judgment” and its pricing as “DMEPOS fee schedule – DME supplies (price subject to floors and ceilings)”. Coverage and payment still depend on the patient, the setting, the documentation and the payer.
Which HCPCS Level II release does this page use?
It uses CMS’s October 2026 release, in effect from Oct 1, 2026 to Dec 31, 2026. It is a reference: confirm the code against the current list and the payer’s rules before you submit it.
Codes beside A4221
All A codesA4213Syringe, sterile, 20 cc or greater, eachA4215Needle, sterile, any size, eachA4216Sterile water, saline and/or dextrose, diluent/flush, 10 mlA4217Sterile water/saline, 500 mlA4218Sterile saline or water, metered dose dispenser, 10 mlA4220Refill kit for implantable infusion pumpA4222Infusion supplies for external drug infusion pump, per cassette or bag (list drugs separately)A4223Infusion supplies not used with external infusion pump, per cassette or bag (list drugs separately)A4224Supplies for maintenance of insulin infusion catheter, per weekA4225Supplies for external insulin infusion pump, syringe type cartridge, sterile, eachA4226Supplies for maintenance of insulin infusion pump with dosage rate adjustment using therapeutic continuous glucose sensing, per weekA4228Supplies for maintenance of non-insulin, device-drug combination infusion catheter, per week