D57.45 ICD-10-CM Code: Sickle-cell thalassemia beta plus with crisis
A clear reference for the official code description, hierarchy, and related coding information from the FY 2027 U.S. release.
Code definition
Official description
D57.45Sickle-cell thalassemia beta plus with crisis
ICD-10-CM diagnosis code · United States clinical modification
Classification
Where D57.45 sits
- 1
Chapter 3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- 2
Section
Hemolytic anemias (D55-D59)
- 3
Category D57
Sickle-cell disorders
- 4
Subcategory D57.4
Sickle-cell thalassemia
- 5
Code D57.45
Sickle-cell thalassemia beta plus with crisis
More specific choices
Codes under D57.45
D57.45 is a non-billable category. Choose the child code that best matches the documented diagnosis.
D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
D57.452Sickle-cell thalassemia beta plus with splenic sequestration
D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57.454Sickle-cell thalassemia beta plus with dactylitis
D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
Documentation details
Notes for this code
Inclusion terms
- HbS-beta plus with crisis
- Sickle-cell beta plus with crisis
Code first
No “code first” instruction is listed for D57.45.
Use additional code
No “use additional code” instruction is listed for D57.45.
Excludes1
Conditions that should not be reported together with this code.
No Excludes1 note is listed for D57.45.
Excludes2
Conditions not included here that may be reported separately when present.
No Excludes2 note is listed for D57.45.
Transparency
Source and release
This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.
Review the CDC/NCHS ICD-10-CM sourceCode-specific guidance
Frequently asked questions
What does ICD-10-CM code D57.45 mean?
D57.45 is the FY 2027 U.S. ICD-10-CM code for “Sickle-cell thalassemia beta plus with crisis.”
Is D57.45 a billable or specific ICD-10-CM code?
No. D57.45 has more specific child codes in the FY 2027 reference data. Select the code that matches the documentation and confirm the active code set and payer requirements.
Where is D57.45 located in ICD-10-CM?
D57.45 is listed in Chapter 3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), within Hemolytic anemias (D55-D59) (D55–D59), under category D57, Sickle-cell disorders and subcategory D57.4, Sickle-cell thalassemia.
What coding notes are listed for D57.45?
Its listed inclusion terms are HbS-beta plus with crisis; Sickle-cell beta plus with crisis. No code-first instruction is listed. No Excludes1 note is listed. No Excludes2 note is listed.
Keep exploring
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