U.S. ICD-10-CM · FY 2027

D57.4 ICD-10-CM Code: Sickle-cell thalassemia

A clear reference for the official code description, hierarchy, and related coding information from the FY 2027 U.S. release.

Code definition

Official description

D57.4

Sickle-cell thalassemia

ICD-10-CM diagnosis code · United States clinical modification

Classification

Where D57.4 sits

  1. 1

    Chapter 3

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

  2. 2

    Section

    Hemolytic anemias (D55-D59)

  3. 3

    Category D57

    Sickle-cell disorders

  4. 4

    Code D57.4

    Sickle-cell thalassemia

More specific choices

Codes under D57.4

D57.4 is a non-billable category. Choose the child code that best matches the documented diagnosis.

D57.40

Sickle-cell thalassemia without crisis

D57.41

Sickle-cell thalassemia, unspecified, with crisis

D57.42

Sickle-cell thalassemia beta zero without crisis

D57.43

Sickle-cell thalassemia beta zero with crisis

D57.44

Sickle-cell thalassemia beta plus without crisis

D57.45

Sickle-cell thalassemia beta plus with crisis

Documentation details

Notes for this code

Inclusion terms

  • Sickle-cell beta thalassemia
  • Thalassemia Hb-S disease

Code first

No “code first” instruction is listed for D57.4.

Use additional code

No “use additional code” instruction is listed for D57.4.

Excludes1

Conditions that should not be reported together with this code.

No Excludes1 note is listed for D57.4.

Excludes2

Conditions not included here that may be reported separately when present.

No Excludes2 note is listed for D57.4.

Transparency

Source and release

Data release

U.S. ICD-10-CM · FY 2027

Effective date

Oct 1, 2026

Publisher

Vero Scribe Inc.

This reference is generated from Vero’s ICD-10-CM description, hierarchy, and code-note dataset. The visible content and structured data share that source.

Review the CDC/NCHS ICD-10-CM source

Code-specific guidance

Frequently asked questions

What does ICD-10-CM code D57.4 mean?

D57.4 is the FY 2027 U.S. ICD-10-CM code for “Sickle-cell thalassemia.”

Is D57.4 a billable or specific ICD-10-CM code?

No. D57.4 has more specific child codes in the FY 2027 reference data. Select the code that matches the documentation and confirm the active code set and payer requirements.

Where is D57.4 located in ICD-10-CM?

D57.4 is listed in Chapter 3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), within Hemolytic anemias (D55-D59) (D55–D59), under category D57, Sickle-cell disorders.

What coding notes are listed for D57.4?

Its listed inclusion terms are Sickle-cell beta thalassemia; Thalassemia Hb-S disease. No code-first instruction is listed. No Excludes1 note is listed. No Excludes2 note is listed.

Keep exploring

Related D57 codes

D57.0

Hb-SS disease with crisis

D57.1

Sickle-cell disease without crisis

D57.2

Sickle-cell/Hb-C disease

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